The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast.
Identifieur interne : 000F60 ( Main/Exploration ); précédent : 000F59; suivant : 000F61The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast.
Auteurs : Avital Horowitz [Canada] ; Jason F. Lapointe [Canada] ; Rawan Eid [Canada] ; Sara Sheibani [Canada] ; Nada Gharib [Canada] ; Natalie K. Jones [Canada] ; Hojatollah Vali [Canada] ; Craig A. Mandato [Canada] ; Michael T. Greenwood [Canada]Source :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2013.
Descripteurs français
- KwdFr :
- Caspases (déficit), Caspases (métabolisme), Cuivre (toxicité), Données de séquences moléculaires (MeSH), Exons (génétique), Humains (MeSH), Introns (génétique), Isoformes de protéines (métabolisme), Mutation (génétique), Protéine Bax (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines du cycle cellulaire (composition chimique), Protéines du cycle cellulaire (métabolisme), Protéines membranaires (métabolisme), Résistance des champignons aux médicaments (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (cytologie), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (métabolisme), Septines (composition chimique), Septines (métabolisme), Sirolimus (pharmacologie), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH), dGTPases (métabolisme), Épissage alternatif (génétique).
- MESH :
- composition chimique : Protéines du cycle cellulaire, Septines.
- cytologie : Saccharomyces cerevisiae.
- déficit : Caspases.
- effets des médicaments et des substances chimiques : Résistance des champignons aux médicaments, Saccharomyces cerevisiae.
- génétique : Exons, Introns, Mutation, Épissage alternatif.
- métabolisme : Caspases, Isoformes de protéines, Protéine Bax, Protéines de Saccharomyces cerevisiae, Protéines du cycle cellulaire, Protéines membranaires, Saccharomyces cerevisiae, Septines, dGTPases.
- pharmacologie : Sirolimus.
- toxicité : Cuivre.
- Données de séquences moléculaires, Humains, Séquence d'acides aminés, Séquence nucléotidique.
English descriptors
- KwdEn :
- Alternative Splicing (genetics), Amino Acid Sequence (MeSH), Base Sequence (MeSH), Caspases (deficiency), Caspases (metabolism), Cell Cycle Proteins (chemistry), Cell Cycle Proteins (metabolism), Copper (toxicity), Drug Resistance, Fungal (drug effects), Exons (genetics), GTP Phosphohydrolases (metabolism), Humans (MeSH), Introns (genetics), Membrane Proteins (metabolism), Molecular Sequence Data (MeSH), Mutation (genetics), Protein Isoforms (metabolism), Saccharomyces cerevisiae (cytology), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (metabolism), Septins (chemistry), Septins (metabolism), Sirolimus (pharmacology), bcl-2-Associated X Protein (metabolism).
- MESH :
- chemical , chemistry : Cell Cycle Proteins, Septins.
- chemical , deficiency : Caspases.
- cytology : Saccharomyces cerevisiae.
- drug effects : Drug Resistance, Fungal, Saccharomyces cerevisiae.
- genetics : Alternative Splicing, Exons, Introns, Mutation.
- chemical , metabolism : Caspases, Cell Cycle Proteins, GTP Phosphohydrolases, Membrane Proteins, Protein Isoforms, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Septins, bcl-2-Associated X Protein.
- chemical , pharmacology : Sirolimus.
- chemical , toxicity : Copper.
- Amino Acid Sequence, Base Sequence, Humans, Molecular Sequence Data.
Abstract
The mechanisms of programmed cell death activate genetically encoded intracellular programs in a controlled manner, the most common form being apoptosis. Apoptosis is carried out through a cascade of caspase mediated proteolytic cleavages initiated by the oligomerization of Bax, a cardinal regulator of mitochondrial-mediated apoptosis. Heterologous expression of Bax in yeast causes cell death that shares a number of similarities to processes that occur in mammalian apoptosis. A screen of a cardiac cDNA library for suppressors of Bax-mediated apoptosis identified human septin7, a protein that belongs to the septin superfamily of conserved GTP-binding proteins that share a conserved cdc/septin domain. Analysis of the amino acid sequence deduced from the septin7 clone as well as the corresponding human septin7 gene revealed that a novel alternatively spliced transcript called septin7 variant4 (v4) was uncovered. Yeast cells overexpressing the human septin7 v4 cDNA were also capable of resisting copper-mediated cell death suggesting that it is not only a Bax suppressor but also an anti-apoptotic sequence. Analysis of septin7 function in a MCA1Δ yeast strain suggests that septin7 inhibits apoptosis in a caspase independent pathway. Overexpression of the yeast septin7 ortholog CDC10 also conferred resistance to the negative effects of copper as well as protecting cells from the overexpression of Bax. In contrast, septin7 was unable to prevent the increase in cell size associated with mutants lacking the endogenous yeast CDC10 gene. Taken together, our analysis suggests that anti-apoptosis is a novel yet evolutionarily conserved property of the septin7 sub-family of septins.
DOI: 10.1016/j.bbamcr.2013.09.004
PubMed: 24055994
Affiliations:
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Le document en format XML
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Lapointe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Eid, Rawan" sort="Eid, Rawan" uniqKey="Eid R" first="Rawan" last="Eid">Rawan Eid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Sheibani, Sara" sort="Sheibani, Sara" uniqKey="Sheibani S" first="Sara" last="Sheibani">Sara Sheibani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Gharib, Nada" sort="Gharib, Nada" uniqKey="Gharib N" first="Nada" last="Gharib">Nada Gharib</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Natalie K" sort="Jones, Natalie K" uniqKey="Jones N" first="Natalie K" last="Jones">Natalie K. Jones</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Vali, Hojatollah" sort="Vali, Hojatollah" uniqKey="Vali H" first="Hojatollah" last="Vali">Hojatollah Vali</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Mandato, Craig A" sort="Mandato, Craig A" uniqKey="Mandato C" first="Craig A" last="Mandato">Craig A. Mandato</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Greenwood, Michael T" sort="Greenwood, Michael T" uniqKey="Greenwood M" first="Michael T" last="Greenwood">Michael T. Greenwood</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada. Electronic address: michael.greenwood@rmc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alternative Splicing (genetics)</term><term>Amino Acid Sequence (MeSH)</term><term>Base Sequence (MeSH)</term><term>Caspases (deficiency)</term><term>Caspases (metabolism)</term><term>Cell Cycle Proteins (chemistry)</term><term>Cell Cycle Proteins (metabolism)</term><term>Copper (toxicity)</term><term>Drug Resistance, Fungal (drug effects)</term><term>Exons (genetics)</term><term>GTP Phosphohydrolases (metabolism)</term><term>Humans (MeSH)</term><term>Introns (genetics)</term><term>Membrane Proteins (metabolism)</term><term>Molecular Sequence Data (MeSH)</term><term>Mutation (genetics)</term><term>Protein Isoforms (metabolism)</term><term>Saccharomyces cerevisiae (cytology)</term><term>Saccharomyces cerevisiae (drug effects)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Septins (chemistry)</term><term>Septins (metabolism)</term><term>Sirolimus (pharmacology)</term><term>bcl-2-Associated X Protein (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Caspases (déficit)</term><term>Caspases (métabolisme)</term><term>Cuivre (toxicité)</term><term>Données de séquences moléculaires (MeSH)</term><term>Exons (génétique)</term><term>Humains (MeSH)</term><term>Introns (génétique)</term><term>Isoformes de protéines (métabolisme)</term><term>Mutation (génétique)</term><term>Protéine Bax (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Protéines du cycle cellulaire (composition chimique)</term><term>Protéines du cycle cellulaire (métabolisme)</term><term>Protéines membranaires (métabolisme)</term><term>Résistance des champignons aux médicaments (effets des médicaments et des substances chimiques)</term><term>Saccharomyces cerevisiae (cytologie)</term><term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Septines (composition chimique)</term><term>Septines (métabolisme)</term><term>Sirolimus (pharmacologie)</term><term>Séquence d'acides aminés (MeSH)</term><term>Séquence nucléotidique (MeSH)</term><term>dGTPases (métabolisme)</term><term>Épissage alternatif (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cell Cycle Proteins</term><term>Septins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Caspases</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Protéines du cycle cellulaire</term><term>Septines</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Fungal</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Caspases</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Résistance des champignons aux médicaments</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alternative Splicing</term><term>Exons</term><term>Introns</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Exons</term><term>Introns</term><term>Mutation</term><term>Épissage alternatif</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspases</term><term>Cell Cycle Proteins</term><term>GTP Phosphohydrolases</term><term>Membrane Proteins</term><term>Protein Isoforms</term><term>Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae Proteins</term><term>Septins</term><term>bcl-2-Associated X Protein</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caspases</term><term>Isoformes de protéines</term><term>Protéine Bax</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines du cycle cellulaire</term><term>Protéines membranaires</term><term>Saccharomyces cerevisiae</term><term>Septines</term><term>dGTPases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Copper</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Cuivre</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Base Sequence</term><term>Humans</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term><term>Humains</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanisms of programmed cell death activate genetically encoded intracellular programs in a controlled manner, the most common form being apoptosis. Apoptosis is carried out through a cascade of caspase mediated proteolytic cleavages initiated by the oligomerization of Bax, a cardinal regulator of mitochondrial-mediated apoptosis. Heterologous expression of Bax in yeast causes cell death that shares a number of similarities to processes that occur in mammalian apoptosis. A screen of a cardiac cDNA library for suppressors of Bax-mediated apoptosis identified human septin7, a protein that belongs to the septin superfamily of conserved GTP-binding proteins that share a conserved cdc/septin domain. Analysis of the amino acid sequence deduced from the septin7 clone as well as the corresponding human septin7 gene revealed that a novel alternatively spliced transcript called septin7 variant4 (v4) was uncovered. Yeast cells overexpressing the human septin7 v4 cDNA were also capable of resisting copper-mediated cell death suggesting that it is not only a Bax suppressor but also an anti-apoptotic sequence. Analysis of septin7 function in a MCA1Δ yeast strain suggests that septin7 inhibits apoptosis in a caspase independent pathway. Overexpression of the yeast septin7 ortholog CDC10 also conferred resistance to the negative effects of copper as well as protecting cells from the overexpression of Bax. In contrast, septin7 was unable to prevent the increase in cell size associated with mutants lacking the endogenous yeast CDC10 gene. Taken together, our analysis suggests that anti-apoptosis is a novel yet evolutionarily conserved property of the septin7 sub-family of septins. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24055994</PMID><DateCompleted><Year>2014</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-3002</ISSN><JournalIssue CitedMedium="Print"><Volume>1833</Volume><Issue>12</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Biochimica et biophysica acta</Title><ISOAbbreviation>Biochim Biophys Acta</ISOAbbreviation></Journal><ArticleTitle>The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast.</ArticleTitle><Pagination><MedlinePgn>3186-3194</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0167-4889(13)00326-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbamcr.2013.09.004</ELocationID><Abstract><AbstractText>The mechanisms of programmed cell death activate genetically encoded intracellular programs in a controlled manner, the most common form being apoptosis. Apoptosis is carried out through a cascade of caspase mediated proteolytic cleavages initiated by the oligomerization of Bax, a cardinal regulator of mitochondrial-mediated apoptosis. Heterologous expression of Bax in yeast causes cell death that shares a number of similarities to processes that occur in mammalian apoptosis. A screen of a cardiac cDNA library for suppressors of Bax-mediated apoptosis identified human septin7, a protein that belongs to the septin superfamily of conserved GTP-binding proteins that share a conserved cdc/septin domain. Analysis of the amino acid sequence deduced from the septin7 clone as well as the corresponding human septin7 gene revealed that a novel alternatively spliced transcript called septin7 variant4 (v4) was uncovered. Yeast cells overexpressing the human septin7 v4 cDNA were also capable of resisting copper-mediated cell death suggesting that it is not only a Bax suppressor but also an anti-apoptotic sequence. Analysis of septin7 function in a MCA1Δ yeast strain suggests that septin7 inhibits apoptosis in a caspase independent pathway. Overexpression of the yeast septin7 ortholog CDC10 also conferred resistance to the negative effects of copper as well as protecting cells from the overexpression of Bax. In contrast, septin7 was unable to prevent the increase in cell size associated with mutants lacking the endogenous yeast CDC10 gene. Taken together, our analysis suggests that anti-apoptosis is a novel yet evolutionarily conserved property of the septin7 sub-family of septins. </AbstractText><CopyrightInformation>© 2013.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Horowitz</LastName><ForeName>Avital</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lapointe</LastName><ForeName>Jason F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eid</LastName><ForeName>Rawan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sheibani</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gharib</LastName><ForeName>Nada</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Natalie K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vali</LastName><ForeName>Hojatollah</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mandato</LastName><ForeName>Craig A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greenwood</LastName><ForeName>Michael T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Chemical Engineering, Royal Military College, Kingston, Ontario, Canada. Electronic address: michael.greenwood@rmc.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta</MedlineTA><NlmUniqueID>0217513</NlmUniqueID><ISSNLinking>0006-3002</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018797">Cell Cycle Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020033">Protein Isoforms</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051028">bcl-2-Associated X Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>789U1901C5</RegistryNumber><NameOfSubstance UI="D003300">Copper</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D020169">Caspases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="C512892">CDC10 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="D020558">GTP Phosphohydrolases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="C113158">SEPTIN7 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="D058112">Septins</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017398" MajorTopicYN="N">Alternative Splicing</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020169" MajorTopicYN="N">Caspases</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018797" MajorTopicYN="N">Cell Cycle Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003300" MajorTopicYN="N">Copper</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025141" MajorTopicYN="N">Drug Resistance, Fungal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005091" MajorTopicYN="N">Exons</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020558" MajorTopicYN="N">GTP Phosphohydrolases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007438" MajorTopicYN="N">Introns</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020033" MajorTopicYN="N">Protein Isoforms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058112" MajorTopicYN="N">Septins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051028" MajorTopicYN="N">bcl-2-Associated X Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-apoptosis</Keyword><Keyword MajorTopicYN="N">Anti-apoptotic</Keyword><Keyword MajorTopicYN="N">Apoptosis</Keyword><Keyword MajorTopicYN="N">Cell size</Keyword><Keyword MajorTopicYN="N">Cell survival</Keyword><Keyword MajorTopicYN="N">Programmed cell death</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>07</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>09</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>09</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24055994</ArticleId><ArticleId IdType="pii">S0167-4889(13)00326-1</ArticleId><ArticleId IdType="doi">10.1016/j.bbamcr.2013.09.004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Horowitz, Avital" sort="Horowitz, Avital" uniqKey="Horowitz A" first="Avital" last="Horowitz">Avital Horowitz</name></region><name sortKey="Eid, Rawan" sort="Eid, Rawan" uniqKey="Eid R" first="Rawan" last="Eid">Rawan Eid</name><name sortKey="Gharib, Nada" sort="Gharib, Nada" uniqKey="Gharib N" first="Nada" last="Gharib">Nada Gharib</name><name sortKey="Greenwood, Michael T" sort="Greenwood, Michael T" uniqKey="Greenwood M" first="Michael T" last="Greenwood">Michael T. Greenwood</name><name sortKey="Jones, Natalie K" sort="Jones, Natalie K" uniqKey="Jones N" first="Natalie K" last="Jones">Natalie K. Jones</name><name sortKey="Lapointe, Jason F" sort="Lapointe, Jason F" uniqKey="Lapointe J" first="Jason F" last="Lapointe">Jason F. Lapointe</name><name sortKey="Mandato, Craig A" sort="Mandato, Craig A" uniqKey="Mandato C" first="Craig A" last="Mandato">Craig A. Mandato</name><name sortKey="Sheibani, Sara" sort="Sheibani, Sara" uniqKey="Sheibani S" first="Sara" last="Sheibani">Sara Sheibani</name><name sortKey="Vali, Hojatollah" sort="Vali, Hojatollah" uniqKey="Vali H" first="Hojatollah" last="Vali">Hojatollah Vali</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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